Your Location：Home > Products > Pharmaceutical intermediates >145108-58-3
Product Details
|
Biological Activity |
Active isomer of Medetomide (4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazolehydrochloride ), a potent, highly selective α 2 -adrenoceptor agonist (K i values are 1.08 and 1750 nM for α 2 - and α 1 -adrenoceptors respectively). Displays greater selectivity over α 1 -adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Active in vivo ; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects. |
|
Biochem/physiol Actions |
Dexmedetomidine hydrochloride is a highly potent and selective α2-adrenergic agonist with analgesic and sedative properties, the (+)-isomer of medetomidine. Dexmedetomidine hydrochloride is used clinically as an anesthetic agent to reduce anxiety and tension and promote relaxation and sedation without causing respiratory depression. |
|
Brand name |
Precedex |
InChI:InChI=1/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13;/h4-8,11H,1-3H3,(H,14,15);1H/t11-;/m0./s1
The invention discloses a preparation me...
The invention belongs to the technical f...
The invention discloses an industrial pr...
The invention provides a method for prep...
4-<1-(2,3-dimethylphenyl)-1-hydroxyethyl>-1-(triphenylmethyl)imidazole
![(-)-(R)-4-(1-[2,3-dimethylphenyl]ethyl)-1H-imidazole hydrochloride](/upload/2025/12/90d25f59-2622-413c-a3ea-fc06aebe23b5.png)
(-)-(R)-4-(1-[2,3-dimethylphenyl]ethyl)-1H-imidazole hydrochloride
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 4 steps
1: triethylsilane; trifluoroacetic acid / dichloromethane / 5 h / -10 - 20 °C
2: hydrogen; palladium 10% on activated carbon
3: ethanol / 20 °C
4: sodium hydroxide / water / pH 8.5
With
triethylsilane; palladium 10% on activated carbon; hydrogen; trifluoroacetic acid; sodium hydroxide;
In
ethanol; dichloromethane; water;
|
![tert-butyl 4-[1-(2,3-dimethylphenyl)-1-hydroxyethyl]-1H-imidazole-1-carboxylate](/upload/2025/12/b4d9a64b-0f1b-4f12-a42a-cc63d556540a.png)
tert-butyl 4-[1-(2,3-dimethylphenyl)-1-hydroxyethyl]-1H-imidazole-1-carboxylate
(-)-(R)-4-(1-[2,3-dimethylphenyl]ethyl)-1H-imidazole hydrochloride
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 3 steps
1: hydrogen; palladium 10% on activated carbon
2: ethanol / 20 °C
3: sodium hydroxide / water / pH 8.5
With
palladium 10% on activated carbon; hydrogen; sodium hydroxide;
In
ethanol; water;
|
1-N,N-Dimethylsulfamoyl-2-(tert-butyldimethylsilyl)-5-(2,3-dimethylbenzoyl)imidazole
1-(1-chloroethyl)-2,3-dimethylbenzene
4-<1-(2,3-dimethylphenyl)-1-hydroxyethyl>-1-(triphenylmethyl)imidazole
tert-butyl 4-acetyl-1H-imidazole-1-carboxylate
CAS：16595-80-5
CAS：153-98-0
CAS：61-12-1
CAS：86347-15-1?
