What is the 2-Acetylbutyrolactone?

2-Acetylbutyrolactone is Colorless to light yellow liquid, while it's Molecular Formula is C6H8O3. Colorless to light yellow liquid In synthesis of 3,4-disubstituted pyridines; of 5-(b-hydroxethyl)-4-methylthiazole.

What is the CAS number for 2-Acetylbutyrolactone?

The CAS number of 2-Acetylbutyrolactone is 517-23-7.

What is 2-Acetylbutyrolactone (517-23-7) used for?

It is an important intermediate involved in the synthesis of chemical and pharmaceutical products such as vitamin B, 3,4-substituted pyridine, 5-(2-Hydroxyethyl)-4-methylthiazole. In presence of 2-acetylbutyrolactone, reaction of tert-butyl isocyanide with dialkyl acetylenedicarboxylates leads to the formation of dialkyl (E)-2-{(tert-butylamino)[2-oxo-4,5-dihydro-3(2H)-furanylidene]methyl}-2-butenedioates.1 Moreover, reaction of 2-acetylbutyrolactone with thiosemicarbazide and 3-(2-bromo-acetyl)-chromen-2-one in anhydrous ethanol produced 3-{2-[5-hydroxyl-4-(2-hydroxyl-ethyl)-3-methyl-pyrazol-1-yl]-thiazol-4-yl}-chromen-2-one in good yields.2 In addition, 2-acetylbutyrolactone can also function as the raw material for synthesizing pilocarpine that is a leading therapeutic agent for the treatment of narrow and wide angle glaucoma.3 Besides, this chemical can also act as a fluorogenic reagent in the quantitative spectrofluorometric determination of primary amines, which has been demonstrated to be equally accurate and precise as the officially or other reported methods.4InChI:InChI=1/C6H8O3/c1-4(7)5-2-3-9-6(5)8/h5H,2-3H2,1H3/t5-/m0/s1

What is the 2-Acetylbutyrolactone?

2-Acetylbutyrolactone is Colorless to light yellow liquid, while it's Molecular Formula is C6H8O3. Colorless to light yellow liquid In synthesis of 3,4-disubstituted pyridines; of 5-(b-hydroxethyl)-4-methylthiazole.

What is the CAS number for 2-Acetylbutyrolactone?

The CAS number of 2-Acetylbutyrolactone is 517-23-7.

What is 2-Acetylbutyrolactone (517-23-7) used for?

It is an important intermediate involved in the synthesis of chemical and pharmaceutical products such as vitamin B, 3,4-substituted pyridine, 5-(2-Hydroxyethyl)-4-methylthiazole. In presence of 2-acetylbutyrolactone, reaction of tert-butyl isocyanide with dialkyl acetylenedicarboxylates leads to the formation of dialkyl (E)-2-{(tert-butylamino)[2-oxo-4,5-dihydro-3(2H)-furanylidene]methyl}-2-butenedioates.1 Moreover, reaction of 2-acetylbutyrolactone with thiosemicarbazide and 3-(2-bromo-acetyl)-chromen-2-one in anhydrous ethanol produced 3-{2-[5-hydroxyl-4-(2-hydroxyl-ethyl)-3-methyl-pyrazol-1-yl]-thiazol-4-yl}-chromen-2-one in good yields.2 In addition, 2-acetylbutyrolactone can also function as the raw material for synthesizing pilocarpine that is a leading therapeutic agent for the treatment of narrow and wide angle glaucoma.3 Besides, this chemical can also act as a fluorogenic reagent in the quantitative spectrofluorometric determination of primary amines, which has been demonstrated to be equally accurate and precise as the officially or other reported methods.4InChI:InChI=1/C6H8O3/c1-4(7)5-2-3-9-6(5)8/h5H,2-3H2,1H3/t5-/m0/s1

2-Acetylbutyrolactone 517-23-7 with purity >99% Low price in stock

Product Details

Quick Details

CasNo： 517-23-7
Molecular Formula： C₆H₈O₃
Appearance： Colorless to light yellow liquid
Purity： 99%

2-Acetylbutyrolactone 517-23-7 with purity >99% Low price in stock

Molecular Formula:C6H8O3
Molecular Weight:128.128
Appearance/Colour:Colorless to light yellow liquid
Vapor Pressure:0.0186mmHg at 25°C
Melting Point:<25 °C
Refractive Index:1.4580 - 1.4620
Boiling Point:253.078 °C at 760 mmHg
PKA:12.00±0.20(Predicted)
Flash Point:128.244 °C
PSA：43.37000
Density:1.191 g/cm³
LogP:0.13850

2-Acetylbutyrolactone(Cas 517-23-7) Usage

Reference

Asghari, S.; Mohammadi, L., Reaction of tert-butyl isocyanide and dialkyl acetylenedicarboxylates in the presence of 2-acetylbutyrolactone. Synthesis of functionalized alpha-methylene-gamma-butyrolactones. Tetrahedron Lett. 2006, 47, 4297-4299. Rao, V. R.; Kumar, P. V., Facile one-pot synthesis of 3-{25-hydroxy-4-(2-hydroxy-ethyl)-3-methyl-pyrazol-1-yl -thiazol-4-yl} -chromen-2-ones via a three-component reaction. Synth. Commun. 2006, 36, 2157-2161. Horne, D. A.; Fugmann, B.; Yakushijin, K.; Buchi, G., A SYNTHESIS OF PILOCARPINE. J. Org. Chem. 1993, 58, 62-64. Sabry, S. M., Application of 2-acetylbutyrolactone to spectrofluorinietry: Fluorescence properties of Schiff bases derived from 2-acetylbutyrolactone and spectrofluorimetric determination of primary amine-containing compounds. J. Pharm. Biomed. Anal. 2006, 40, 1057-1067.

Flammability and Explosibility

Notclassified

InChI:InChI=1/C6H8O3/c1-4(7)5-2-3-9-6(5)8/h5H,2-3H2,1H3/t5-/m0/s1

517-23-7 Relevant articles

Application of liquid sodium methoxide in synthesis of alpha-acetyl-gamma-butyrolactone and synthesis method of alpha-acetyl-gamma-butyrolactone

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Paragraph 0085-0106, (2021/05/08)

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Preparation method of alpha-acetyl-gamma-butyrolactone

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Paragraph 0022-0047, (2018/04/21)

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517-23-7 Process route

: 96-48-0
4-butanolide

: 79-20-9
acetic acid methyl ester

: 517-23-7,594837-91-9,98634-97-0,313643-49-1
3-acetyl-2-oxo-4,5-dihydrofuran

Conditions

Conditions	Yield
4-butanolide; acetic acid methyl ester; With sodium methylate; In methanol; at 45 - 90 ℃; for 10h; under 750.075 Torr; Inert atmosphere; Large scale; With carbon dioxide; In methanol; water; at 0 - 35 ℃; for 0.5h; under 6000.6 Torr; Temperature; Pressure; Reagent/catalyst; Large scale;	96%
With sodium methylate; at 85 ℃; for 4h;	96%

: 96-48-0
4-butanolide

: 75-07-0,9002-91-9
acetaldehyde

: 517-23-7,594837-91-9,98634-97-0,313643-49-1
3-acetyl-2-oxo-4,5-dihydrofuran

Conditions

Conditions	Yield
With sodium hydrogencarbonate; In ethyl acetate; at 60 - 95 ℃; for 3.5h; under 750.075 - 7500.75 Torr; Solvent; Temperature; Reagent/catalyst; Autoclave;	79.31%