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Mirtazapine is white crystalline solid, while it's Molecular Formula is C17H19N3. antidepressant;antagonist at the H1, 5-HT2A, 5-HT2C, 5-HT3, and a2-adrenergic receptors, in that order of potency
The CAS number of Mirtazapine is 61337-67-5.
More information of Mirtazapine 61337-67-5 are:
|
Synonyms |
Mirtabene;2-Methyl-1,2,3,4,10,14b-hexahydropyrazino[2,1-a]pyrido[2,3-c][2]benzazepine; |
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CAS Number |
61337-67-5 |
|
Molecular Formula |
C17H19N3 |
|
Molecular Weight |
265.358 |
|
Density |
1.22 g/cm3 |
|
Melting Point |
114-116 °C |
|
Boiling Point |
432.4 °C at 760 mmHg |
|
Flash Point |
215.3 °C |
|
HS CODE |
2933990090 |
|
PSA |
19.37000 |
|
LogP |
2.48180 |
|
Pka |
pKa 7.1(47% MeOH in H2O,t =25,I=0.15(KCl)) (Uncertain) |
Mirtazapine is an antidepressant launched in the Netherlands. Mirtazapine is a potent antagonist of presynaptic α2 receptors as well as a moderately potent 5-HT antagonist. Studies suggested that blockade of α2-adrenoceptors, but not inhibition of noradrenaline uptake, is involved in the mechanism of the antidepressant action of mirtazapine. Mirtazapine has demonstrated efficacy in various studies in depressed patients, being equal or more potent than mianserin, amitriptyline, etc. and exhibiting less anticholinergic and gastrointestinal side effects and low cardiovascular toxicity. In addition to its antidepressant effects, studies in animals indicated that mirtazapine has anxiolytic andor hypnotic activity.
InChI:InChI=1/C17H19N3/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-18-17(14)20/h2-8,16H,9-12H2,1H3/p+2/t16-/m0/s1
Articles related to Mirtazapine:
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Article |
Source |
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Improved synthesis of mirtazapine |
Srinivasa Rao,Dandala,Handa,Sivakumaran,Raghava Reddyt,Naidu , p. 399 - 402 (2007) |
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Preparation method and intermediate product of mirtazapine |
- Paragraph 0033; 0035-0043, (2020/06/09) |
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